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    It was an emotional day! Some of us have persevered for more than four years to make this happen. The role efflux transporters could fake in the concentration-dependent kinetics of pht is based on scrutinize results, where reduced plasma concentrations of pht were obtained after co application of ciprofloxacin, a well-known transporter inhibitor (pollack and slayter 1997 brouwers et al. Repetitive seizures should be treated with a loading dose of phenobarbital (20 mgkg infused over 30-60 minutes).

    More frequent measurements should be made in the presence of any condition that may significantly alter theophylline clearance (see table i. . Seizures associated with serum theophylline concentrations 30 mcgml are often resistant to anticonvulsant therapy and may result in irreversible brain injury if not rapidly controlled.

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